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signalchemlifesciences

更新時間：2017-04-12

點擊次數：2215

signalchemlifesciences——激酶研究

SignalChem Lifesciences Corporation (“SLC”)公司總部位于加拿大不列顛哥倫比亞，是激酶研究領域的企業，其兩大核心產品系列為生物試劑及研究服務與藥物研發服務部。生物試劑及研究服務（SignalChem Pharmaceuticals Inc）始于2004年，致力于研發和生產生物醫藥研究和藥物研發領域的激酶產品，目前擁有的激酶/表觀遺傳相關酶類及其檢測試劑產品超過2000種，覆蓋幾乎所有激酶靶點以及表觀遺傳研究相關酶類，以及多種信號蛋白相關產品。同時，為輔助檢測激酶及臨床疾病和個體化治療，SignalChem還在生物標志物及診斷試劑盒領域有著數十年的積淀，擁有強大和豐富的相關產品。藥物研發服務部致力于尋找新的小分子激酶抑制劑，并用于臨床治療。憑借公司豐富的激酶特異性小分子復合物資源庫，以及公司在激酶研究領域強大研究團隊和豐富研究經驗，SLC在以激酶及其通路為靶點的藥物設計、研發和生產具有*優勢，目前公司已擁有大量的以激酶為靶點的小分子抑制劑產品，可用于研究各種腫瘤等疾病。蛋白激酶是聯結所有細胞活動的中樞，通過過表達/過度激活及突變蛋白激酶可導致機體功能異常進而引發疾病，因此靶向激酶的藥物有著重要的臨床應用價值。蛋白激酶家族是僅次于G蛋白偶聯受體家族的第二大藥物靶點，目前已發現約518種野生型的激酶族以及與其相關的臨床突變案例，有超過30種FDA認證的激酶抑制劑。憑借著多年來以激酶為核心的細胞信號相關產品研發積累，以及為科研院所及制藥企業科研服務經驗，SignalChem在抑制激酶活性的藥物領域處于水平，公司不僅擁有zui大的且不斷成長的活性激酶及突變激酶產品線，以及可在多個檢測平臺實施的激酶活性檢測試劑盒，而且不斷與多個大型制藥企業和研究院所廣泛合作，公司的主要產及服務包括：

1、憑借公司強大的科研力量和經驗，SignalChem推出的“Kinome Search Engine”激酶篩選系統，可對每一個激酶族中的單個激酶做出檢測，從而輔助和加快激酶藥物的研發。

2、“Kinome Search Engine”激酶篩選系統不僅可輔助設計激酶藥物，還可進一步研究人類激酶族的功能和機制，加深對未知激酶的認識，尋找更多的藥物靶點，（目前認證的藥物僅僅有少于5%是以已知的激酶通路為靶點，因此激酶通路作為藥物靶點有著巨大的潛力和價值）。

3、SignalChem公司擁有激酶相關臨床突變數據庫，在研究疾病復發和抗藥領域的核心問題時有著的優勢，可以更為有效地協助制藥企業進行藥物研發。

除了藥物研發方面的優勢，SignalChem還在生物標志物及診斷試劑盒領域有著數十年的積淀，擁有強大和豐富的相關產品。

目前SLC公司的產品覆蓋了幾乎所有細胞內激酶相關通路，包括AKT/PKB通路、ERK/MAPK通路、JAK/STAT通路、JNK/SAPK通路、NfkB通路、p38通路、PKA/PKC通路、WNT信號通路等，適用于血管再生、凋亡和自噬、腫瘤、心血管疾病、細胞周期、細胞應激、胞內酪氨酸激酶、炎癥、浸潤和轉移、脂質激酶、代謝性疾病、神經生物學、磷酸酶/磷酸二酯酶、受體酪氨酸激酶、Ser/Thr激酶等研究領域。主要產品有：

一、蛋白酶類產品系列

1、高活性乙酰轉移酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
KAT2A (GCN5), Active	K311-381G	Human	GST tag	Sf9 insect cells	323-end	NM_021078
KAT2B (PCAF), Active	K311-381BG	Human	GST tag	Sf9 insect cells	431-end	NM_003884
KAT3A (CREBBP), Active	K312-381G	Human	GST tag	Sf9 insect cells	1319-1710	NM_004380
KAT5 (TIP60), Active	K314-380G	Human	GST tag	Sf9 insect cells	Full Length	NM_006388
KAT6B (MYST4), Active	K315-381BG	Human	GST tag	Sf9 insect cells	431-end	NM_012330
KAT7 (MYST2), Active	K316-380G	Human	GST tag	Sf9 insect cells	Full Length	NM_007067

2、高活性精氨酸脫亞氨酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
PAD Cocktail, Active	P312-37C	-	-	-	Full Length	-

3、高活性GTP/ATP酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
CDC42, Active	C108-310GH	Human	GST/His	E.coli	Full length	NM_001791
GNAI1, Active	G121-310G	Human	GST tag	E.coli	2-end	NM_002069
GNAI2, Active	G122-310G	Human	GST tag	E.coli	2-end	NM_002070
GNAI3, Active	G123-310G	Human	GST tag	E.coli	2-end	NM_006496
GNAS, Active	G127-310G	Human	GST tag	E.coli	Full length	NM_000516
HRAS1 (Mature form), Active	R105-310H	Human	His tag	E.coli	2-186	NM_005343
KRAS (Mature form), Active	R106-310H	Human	His tag	E.coli	2-186	NM_033360
NRAS (Mature form), Active	R107-310H	Human	His tag	E.coli	2-186	NM_002524
RAC1, Active	R103-310G	Human	GST tag	E.coli	Full length	NM_006908
RAC2, Active	R104-310H	Human	His tag	E.coli	Full length	NM_002872
RAC3, Active	R102-310H	Human	His tag	E.coli	Full length	NM_005052
RhoA (Mature form), Active	R144-310H	Human	His tag	E.coli	1-190	NM_001664
RhoC (Mature form), Active	R144-310CH	Human	His tag	E.coli	1-190	NM_175744
RhoD (Mature form), Active	R144-310DH	Human	His tag	E.coli	1-207	BC001338
VCP, Active	V116-310G	Human	GST tag	Sf9 insect cells	Full length	NM_007126

4、高活性組蛋白去乙酰化酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
HDAC1, Active	H83-30G	Human	GST tag	Sf9 insect cells	Full Length	NM_004964
HDAC10, Active	H92-31G	Human	GST tag	Sf9 insect cells	1-482	NM_032019
HDAC11, Active	H93-30G	Human	GST tag	Sf9 insect cells	Full Length	NM_024827
HDAC2, Active	H84-30G	Human	GST tag	Sf9 insect cells	Full Length	NM_001527
HDAC3, Active	H85-30G	Human	GST tag	Sf9 insect cells	Full Length	NM_003883
HDAC3/NCOR2, Active	H85-38G	Human	GST tags	Sf9 insect cells	HDAC3 (full-length)/ NCOR2 (237-489)	NM_003883
HDAC4, Active	H86-31G	Human	GST tag	Sf9 insect cells	612-end	NM_006037
HDAC5, Active	H87-31G	Mouse	GST tag	Sf9 insect cells	617-end	BC060609
HDAC6, Active	H88-30G	Human	GST tag	Sf9 insect cells	Full Length	BC069243
HDAC7, Active	H89-31G	Human	GST tag	Sf9 insect cells	501-end	NM_015401
HDAC8, Active	H90-30H	Human	His tag	Sf9 insect cells	Full Length	BC050433

5、活性突變激酶（共計253種）

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
ABL1 Mutant (E255K), Active	A03-12BG	Human	GST tag	Sf9 insect cells	27-end (E255K)	NM_005157
ABL1 Mutant (E255V), Active	A03-12HH	Human	His tag	Sf9 insect cells	27-end (E255V)	NM_005157
ABL1 Mutant (F317I), Active	A03-12JG	Human	GST tag	Sf9 insect cells	27-end (F317I)	NM_005157
ABL1 Mutant (F317L), Active	A03-12IG	Human	GST tag	Sf9 insect cells	27-end (F317L)	NM_005157
ABL1 Mutant (G250E), Active	A03-12CG	Human	GST tag	Sf9 insect cells	27-end (G250E)	NM_005157
ABL1 Mutant (H396P), Active	A03-12LG	Human	GST tag	Sf9 insect cells	27-end (H396P)	NM_005157
ABL1 Mutant (M351T), Active	A03-12KG	Human	GST tag	Sf9 insect cells	27-end (M351T)	NM_005157
ABL1 Mutant (Q252H), Active	A03-12FG	Human	GST tag	Sf9 insect cells	27-end (Q252H)	NM_005157
ABL1 Mutant (T315I), Active	A03-12DG	Human	GST tag	Sf9 insect cells	27-end (T315I)	NM_005157
ABL1 Mutant (V299L), Active	A03-12MG	Human	GST tag	Sf9 insect cells	27-end (V299L)	NM_005157
ABL1 Mutant (Y253F), Active	A03-12EG	Human	GST tag	Sf9 insect cells	27-end (Y253F)	NM_005157
ABL1 Mutant (Y253H), Active	A03-12GH	Human	His tag	Sf9 insect cells	27-end (Y253H)	NM_005157
AKT1 Mutant (E17K), Active	A16-12G	Human	GST tag	Sf9 insect cells	Full length (E17K)	NM_005163
AKT2 Mutant (E17K), Active	A17-12G	Human	GST tag	Sf9 insect cells	Full length (E17K)	NM_001626
AKT2 Mutant (R274H), Active	A17-12BG	Human	GST tag	Sf9 insect cells	Full length (R274H)	NM_001626
AKT3 Mutant (E17K), Active	A18-12G	Human	GST tag	Sf9 insect cells	Full Length (E17K)	NM_005465
AKT3 Mutant (G171R), Active	A18-12BG	Human	GST tag	Sf9 insect cells	Full length (G171R)	NM_005465
ALK Mutant (C1156Y), Active	A19-12DG	Human	GST tag	Sf9 insect cells	1060-end (C1156Y)	NM_004304
ALK Mutant (F1174L), Active	A19-12EG	Human	GST tag	Sf9 insect cells	1060-end (F1174L)	NM_004304
ALK Mutant (F1174S), Active	A19-12FG	Human	GST tag	Sf9 insect cells	1060-end (F1174S)	NM_004304
ALK Mutant (G1202R), Active	A19-12HG	Human	GST tag	Sf9 insect cells	1060-end (G1202R)	NM_004304
ALK Mutant (G1269A), Active	A19-12JG	Human	GST tag	Sf9 insect cells	1060-end (G1269A)	NM_004304
ALK Mutant (G1269S), Active	A19-12KG	Human	GST tag	Sf9 insect cells	1060-end (G1269S)	NM_004304
ALK Mutant (L1152R), Active	A19-12CG	Human	GST tag	Sf9 insect cells	1060-end (L1152R)	NM_004304
ALK Mutant (L1196M), Active	A19-12GG	Human	GST tag	Sf9 insect cells	1060-end (L1196M)	NM_004304
ALK Mutant (R1275Q), Active	A19-12LG	Human	GST tag	Sf9 insect cells	1060-end (R1275Q)	NM_004304
ALK Mutant (S1206R), Active	A19-12IG	Human	GST tag	Sf9 insect cells	1060-end (S1206R)	NM_004304
ALK Mutant (T1151M), Active	A19-12BG	Human	GST tag	Sf9 insect cells	1060-end (T1151M)	NM_004304
ALK Mutant (T1151_L1152insT), Active	A19-12G	Human	GST tag	Sf9 insect cells	1060-end (T1151_L1152insT)	NM_004304
ALK2 Mutant (PF197_198L), Active	A06-12FG	Human	GST tag	Sf9 insect cells	147-end (PF197_198L)	NM_001105
ALK2 Mutant (Q207D), Active	A06-13CG	Human	GST tag	Sf9 insect cells	147-end (Q207D)	NM_001105
ALK2 Mutant (Q207E), Active	A06-13DG	Human	GST tag	Sf9 insect cells	147-end (Q207E)	NM_001105
ALK2 Mutant (R206H), Active	A06-12BG	Human	GST tag	Sf9 insect cells	147-end (R206H)	NM_001105
ALK3 Mutant (Q233D), Active	B04-12BG	Human	GST tag	Sf9 insect cells	187-end (Q233D)	NM_004329
ALK3 Mutant (R486Q), Active	B04-12CG	Human	GST tag	Sf9 insect cells	187-end (R486Q)	NM_004329
AXL Mutant (R499C), Active	A34-12BG	Human	GST tag	Sf9 insect cells	473-end (R499C)	NM_021913
BCR-RET Mutant, Active	R02-19EG	Human	GST tag	Sf9 insect cells	1-426 (BCR) - 713-end (RET)	BC066122
BRAF Mutant (d485-489 P490Y), Active	B08-12IG	Human	GST tag	Sf9 insect cells	381-end or exon 9-18 (d485-489 P490Y)	NM_004333
BRAF Mutant (G464V), Active	B08-12JG	Human	GST tag	Sf9 insect cells	381-end or exon 9-18 (G464V)	NM_004333
BRAF Mutant (G469A), Active	B08-12FG	Human	GST tag	Sf9 insect cells	381-end or exon 9-18 (G469A)	NM_004333
BRAF Mutant (K601E), Active	B08-12BG	Human	GST tag	Sf9 insect cells	416-end (K601E)	NM_004333
BRAF Mutant (L597V), Active	B08-12HG	Human	GST tag	Sf9 insect cells	381-end or exon 9-18 (L597V)	NM_004333
BRAF Mutant (R506_K507insVLR), Active	B08-13CG	Human	GST tag	Sf9 insect cells	381-end or exon 9-18 (R506_K507insVLR)	NM_004333

6、活性激酶

該產品系列共包括445種激酶產品，下表僅列部分.

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
ABL1, Active	A03-11H	Mouse	His tag	Sf9 insect cells	27-end	NM_009594
ABL1, Active	A03-18H	Human	His tag	Sf9 insect cells	27-end	NM_005157
ABL2, Active	A04-11H	Human	His tag	Sf9 insect cells	38-end	NM_005158
ACK, Active	A05-11G	Human	GST tag	Sf9 insect cells	110-476	NM_005781
AKT1, Active	A16-10G	Human	GST tag	Sf9 insect cells	Full Length	NM_005163
AKT2, Active	A17-10H	Human	His tag	Sf9 insect cells	Full Length	NM_001626
AKT2, Active	A17-10G	Human	GST tag	Sf9 insect cells	Full Length	NM_001626
AKT3, Active	A18-10G	Human	GST tag	Sf9 insect cells	Full Length	NM_005465

7、高活脂質激酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
DGKA, Active	D21-10G	Human	GST tag	Sf9 insect cells	Full length	NM_001345
PI3K (p110 alpha (E545K)/p85 alpha), Active	P27-152H	Human	His tags	Sf9 insect cells	Full length	NM_006218
PI3K (p110 alpha (N345K(/p85 alpha), Active	P27-122CH	Human	His tags	Sf9 insect cells	Full length	NM_006218
PI3K (p110 alpha(E542K)/p85 alpha, Active	P27-122DH	Human	His tags	Sf9 insect cells	Full length	NM_006218
PI3K (p110 alpha/p55 gamma), Active	P27-102CH	Human	His tag	Sf9 insect cells	Full length	NM_006218
PI3K (p110 alpha/p85 alpha), Active	P27-102G	Human	GST tags	Sf9 insect cells	Full length	NM_006218
PI3K (p110 alpha/p85 alpha), Active	P27-102H	Human	His tags	Sf9 insect cells	Full length	NM_006218
PI3K (p110 alpha/p85 alpha), Active	P27-182H	Mouse	His tags	Sf9 insect cells	Full length	NM_008839
PI3K (p110 beta/p85 alpha), Active	P28-102H	Human	His tags	Sf9 insect cells	Full length	NM_006219
PI3K (p110 beta/p85 beta), Active	P28-102BH	Human	His tags	Sf9 insect cells	Full length	NM_006219
PI3K (p110 delta/p85 alpha), Active	P30-102H	Human	His tags	Sf9 insect cells	Full length	NM_005026
PI3K (p120 gamma), Active	P29-102H	Human	His tag	Sf9 insect cells	Full length	NM_002649
PI4K2A, Active	P21-102G	Human	GST tag	Sf9 insect cells	Full length	NM_018425
PI4K2B, Active	P22-102G	Human	GST tag	Sf9 insect cells	Full length	NM_018323
PI4KA, Active	P31-102G	Human	GST tag	Sf9 insect cells	Full length	NM_002650
PI4KB, Active	P32-102G	Human	GST tag	Sf9 insect cells	Full length	BC000029
PIK3C2A, Active	P23-112G	Human	GST tag	Sf9 insect cells	299-end	NM_002645
PIK3C2B, Active	P24-112BG	Human	GST tag	Sf9 insect cells	850-end	BC144342

8、高活性甲基轉移酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
COMT, Active	C339-381G	Human	GST tag	Sf9 insect cells	27-271	NM_000754
DNMT3A, Active	D353-380G	Human	GST tag	Sf9 insect cells	Full Length	BC043617
DNMT3B, Active	D353-380BG	Human	GST tag	Sf9 insect cells	Full Length	BC111933
DNMT3L, Active	D353-380CG	Human	GST tag	Sf9 insect cells	Full Length	BC002560
DOT1L (KMT4), Active	D344-381G	Human	GST tag	Sf9 insect cells	1-435	NM_032482
EHMT1 (KMT1D), Active	E317-381G	Human	GST tag	Sf9 insect cells	895-end	NM_024757
EHMT2, Active	E318-381G	Human	GST tag	Sf9 insect cells	807-end	NM_006709
LCMT1, Active	L321-380G	Human	GST tag	Sf9 insect cells	Full length	NM_016309
MLL1 (KMT2A), Active	M341-381G	Human	GST tag	Sf9 insect cells	3738-end	NM_005933
MLL2 (KMT2D), Active	M342-381G	Human	GST tag	Sf9 insect cells	5317-end	NM_003482
MLL3 (KMT2C), Active	M343-381G	Human	GST tag	Sf9 insect cells	4689-end	NM_170606

9、高活性磷酸酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
CDC2, Active	C04-20G	Human	GST tag	Sf9 insect cells	Full Length	NM_001789
CDC25B, Active	C04-20BG	Human	GST tag	Sf9 insect cells	Full Length	NM_021873
CDC25C, Active	C04-20CG	Human	GST tag	Sf9 insect cells	Full Length	BC019089
DUSP22 (MKPX), Active	D22-20G	Human	GST tag	E.coli	Full Length	NM_020185
PP1A, Active	P13-20G	Human	GST tag	Sf9 insect cells	Full Length	NM_002708
PP1B, Active	P14-20G	Human	GST tag	Sf9 insect cells	Full Length	NM_002709
PP2A alpha/PPP2R1A Complex, Active	P16-20BH	Human	His tags	Sf9 insect cells	Full length	NM_002715
PP2Aalpha, Active	P16-20G	Human	GST tag	Sf9 insect cells	Full Length	NM_002715

10、高活性磷酸二酯酶

品名	貨號	種屬	標記類型	表達系統	氨基序列	基因號
PDE10A, Active	P98-31G	Human	GST tag	Sf9 insect cells	71-end	NM_006661
PDE1A, Active	P89-30H	Human	His tag	Sf9 insect cells	Full Length	NM_005019
PDE1B, Active	P89-30BG	Human	GST tag	Sf9 insect cells	Full Length	NM_000924
PDE1C, Active	P89-30CG	Human	GST tag	Sf9 insect cells	Full Length	NM_005020
PDE2A, Active	P90-30G	Human	GST tag	Sf9 insect cells	Full Length	NM_002599
PDE3A, Active	P91-31G	Human	GST tag	Sf9 insect cells	669-end	NM_000921
PDE3B, Active	P91-31BG	Human	GST tag	Sf9 insect cells	654-end	NM_000922
PDE4A, Active	P92-31G	Human	GST tag	Sf9 insect cells	332-end	NM_001111307
PDE4B, Active	P92-31BG	Human	GST tag	Sf9 insect cells	305-end	NM_002600
PDE4C, Active	P92-31CG	Human	GST tag	Sf9 insect cells	287-end	NM_000923

11、高活性蛋白酶

品名	貨號	種屬	標記類型	表達系統	氨基序列
CPB (carboxypeptidase B), Active	C560-31N	Rat	tag-free	Yeast cells	109-end
EK (enterokinase), Active	E535-31H	Swine	His tag	Yeast cells	800-end
Immobilized Lys-c, Agarose	L585-31AN	Bacteria	tag-free	E.coli	206-473 aa
Immobilized Lys-c, Silica	L585-31SN	Bacteria	tag-free	E.coli	206-473 aa
Immobilized Thrombin, Agarose	T565-31AN	Human	Native
Immobilized Trypsin, Agarose	T575-31AN	Swine	tag-free	Yeast cells	10-end
Immobilized Trypsin, Silica	T575-31SN	Swine	tag-free	Yeast cells	10-end
KEX2 Protease, Active	K525-31N	Yeast	tag-free	Yeast cells	110-660 aa
Lys-c (lysyl-endopeptidase), Active	L585-31N	Bacteria	tag-free	E.coli	206-473 aa

二、抗體產品系列

1、亞型特異性抗體

品名	貨號	宿主	應用
Anti-AKT3	A18-63R	Rabbit	WB
Anti-AMPK alpha 1	P47-63R	Rabbit	WB
Anti-CAMK1	C07-60M	Mouse, IgG1, 5H8	WB
Anti-CHK2	C48-60M	Mouse, IgG1, 7F9	WB
Anti-ERK1	M29-60M	Mouse, IgG1, E32	WB, IP
Anti-ERK1	M29-60BM	Mouse, IgG1, E19	WB, IP
Anti-GSK3 alpha	G08-63R	Rabbit	WB
Anti-GSK3 beta	G09-60M	Mouse, IgG1, 6C2	WB
Anti-HSP90 beta	H36-63R	Rabbit	WB

2、偶聯修飾的抗體

品名	貨號	宿主	應用
Anti-5-Methylated Cytosine (5-methyl cytosine)	C92-67S	Sheep, IgG	WB, IP
Anti-Acetylated Lysine	L95-66R	Rabbit	WB, ELISA, PI, IHC, IF
Anti-Acetylated Lysine, Biotin Conjugated	L95-66BR	Rabbit	WB, ELISA, IF, IHC, IP
Anti-Acetylated Lysine, FITC Conjugated	L95-66CR	Rabbit	For direct immunofluorescence assay
Anti-Acetylated Lysine, HRP Conjugated	L95-66DR	Rabbit	WB, ELISA, IF, IHC, IP
Anti-Methylated Arginine (N^G, N^G-Di-methyl)	A96-67R	Rabbit	WB, ELISA, IF, IHC, IP
Anti-Methylated Arginine (N^G-Mono-methyl)	A95-67R	Rabbit	WB, ELISA, IF, IHC, IP
Anti-Methylated Lysine (Tri- epsilon-N-methyl)	L95-67R	Rabbit	WB, ELISA, IF, IHC, IP

3、磷酸化特異性抗體

該產品系列共包括82款磷酸化特異性抗體，下表僅列部分產品，

品名	貨號	宿主	應用
Anti-phospho-14-3-3 beta (Ser58)	Y71-365R	Rabbit, IgG	WB, IHC
Anti-phospho-4EBP1 (Thr45)	E35-365R	Rabbit, IgG	WB, IHC
Anti-phospho-AKT1/2/3 (Ser473)	A16-65BR	Rabbit, IgG	WB, IHC
Anti-phospho-AKT1/2/3 (Thr308)	A16-65R	Rabbit, IgG	WB, IHC
Anti-phospho-ASK1 (Ser966)	M13-65R	Rabbit, IgG	IHC
Anti-phospho-ATF2 (Ser112)	A10-565R	Rabbit, IgG	IHC
Anti-phospho-ATF2 (Ser490 Ser498)	A10-565BR	Rabbit, IgG	WB, IHC
Anti-phospho-BRCA1 (Ser1423)	B87-365R	Rabbit, IgG	IHC
Anti-phospho-c-KIT (Tyr721)	K06-65R	Rabbit, IgG	WB
Anti-phospho-c-KIT (Tyr936)	K06-65BR	Rabbit, IgG	IHC

4、Primary Antibodies

該產品系列共包括279款原初抗體，下表僅列部分產品

品名	貨號	宿主	應用
Anti-4EBP1	E35-563R	Rabbit, IgG	WB, ELISA, ICC
Anti-ADD1	A38-63R	Rabbit	WB
Anti-AFX	A42-63R	Rabbit	WB
Anti-AKT (pan)	A16-63R	Rabbit	WB
Anti-AKT (pan)	A16-63BR	Rabbit	WB
Anti-AKT1	A16-60M	Mouse, Monoclonal, 9A4	WB
Anti-AKT1	A16-63CR	Rabbit, IgG	WB, ELISA, IF, IHC
Anti-AKT2/3	A17-63BR	Rabbit	WB
Anti-ALK2	A06-63R	Rabbit, IgG	WB, ELISA
Anti-ALK4	A07-63R	Rabbit, IgG	WB, ELISA

5、二抗

品名	貨號	宿主	應用
Anti-Mouse HRP	G32-62G	Goat Polyclonal	WB, ELISA
Anti-Rabbit HRP	G33-62G	Goat Polyclonal	WB, ELISA

6、Tag標簽抗體

品名	貨號	宿主	應用
Anti-DYKDDDDK	F51-61M	Mouse, IgG2b, FG4R	WB, ELISA, IP, IS
Anti-DYKDDDDK	F51-63R	Rabbit	WB
Anti-GFP	G46-60M	Mouse, IgG1, GF28R	WB
Anti-GST	G52-61M	Mouse, IgG2a, G2R	WB
Anti-HA	H98-61M	Mouse, IgG3, C10	WB, ELISA, IP, IS
Anti-HA	H98-63R	Rabbit Polyclonal	WB, ELISA, IP, IS
Anti-His	H99-61M	Mouse, IgG2b, EH158	WB, ELISA, IP, IS
Anti-His	H99-63R	Rabbit	WB, ELISA, IP, IS
Anti-Myc	M86-61M	Mouse, IgG1, M19	WB, ELISA, IP, IS
Anti-RFP	R46-61M	Mouse, IgG1, RF5R	WB
Anti-V5	V05-61M	Mouse, IgG1, V4RR	WB, ELISA, IP, IS

三、生物制劑產品系列

1、表觀遺傳酶激活劑

品名	貨號	CAS 注冊號	分子式	純度
BML-278	S35-904C	N/F	C₂₄H₂₅NO₄	>98% (TLC)
CTPB	P07-903	586976-24-1	C₃₁H₄₃ClF₃NO₂	98%
Resveratrol	S35-904	501-36-0	C₁₄H₁₂O₃	>98%
SirtAct	S35-904E	839699-72-8	C₂₀H₂₅N₅O₂	98% (TLC)

2、表觀遺傳酶抑制劑

該產品系列共包括33款表觀遺傳研究酶類的抑制劑，下表僅列部分產品

品名	貨號	應用
2’-Deoxy-5-fluorocytidine	D353-904D	不可逆DNA甲基轉移酶抑制劑
5-Azacytidine	D353-904	DNA低甲基化試劑
AK-7	S36-904	SIRT2抑制劑
APICIDIN	H83-904B	HDAC抑制劑
BIX-01294 3HCl	S344-903	Histone甲基轉移酶抑制劑
BML-210	H83-904C	HDAC抑制劑
C-646	K311-903	HAT抑制劑
Chaetocin	K421-904C	Ly甲基轉移酶抑制劑
CPTH2	K311-903B	HAT 抑制劑

3、激酶激活劑

品名	貨號	CAS 注冊號	分子式	純度
8-pCPT-2-O-Me-cAMP-AM	R46-905	1152197-23-3	C₂₀H₂₁ClN₅O₈PS	>97% (HPLC)
AICAR	P47-900B	2627-69-2	C₉H₁₄N₄O₅	>99% (TLC); NMR (Conforms)

4、激酶抑制劑

該產品系列共包括80款常用激酶抑制劑，下表僅列部分產品

品名	貨號	應用
6BIO	G08-900	GSK3 inhibitor
A83-01	A09-900	ALK inhibitor
AAL-993	F11-900C	VEGF inhibitor
AG-1296	P12-900	PDGFR Inhibitor
AG-1478	E10-900B	EGFR inhibitor
AG-1517	K11-900B	Tyrosine kinase inhibitor

5、磷酸酶抑制劑

品名	貨號	CAS 注冊號	分子式	純度
Cantharidin	P16-902C	56-25-7	C₁₀H₁₂O₄	>98% (HPLC)
EX-527	S35-904F	49843-98-3	C₁₃H₁₃ClN₂O	98% (TLC)
NSC-663284	C04-902	383907-43-5	C₁₅H₁₆ClN₃O₃	>98%
Okadaic acid, free acid	P16-902	78111-17-8	C₄₄H₆₈O₁₃	>98% (TLC)

6、內參siRNA

品名	貨號
beta-Actin Positive Control siRNA	A03-911D
Cy3 Labeled Negative Control siRNA	S02-910N
FAM Labeled Negative Control siRNA	S03-910N
GAPDH Positive Control siRNA	G13-911B
Unlabeled Negative Control siRNA	S01-910N

7、激酶研究常用siRNA

該產品系列共包括782款常用激酶的siRNA，下表僅列部分產品

品名	貨號
14-3-3 alpha/beta siRNA Set I	Y71-911
14-3-3 epsilon siRNA Set I	Y75-911
14-3-3 sigma siRNA Set I	Y86-911
14-3-3 theta siRNA Set I	Y84-911
14-3-3 zeta siRNA Set I	Y92-911
4EBP1 siRNA Set I	E35-911
AATK siRNA Set I	A02-911
ABL1 siRNA Set I	A03-911
ABL2 siRNA Set I	A04-911
ACK siRNA Set I	A05-911
ACVR2A siRNA Seti	A35-911

四、信號通路蛋白及酶

該產品系列包括目前常用的信號通路蛋白及相關酶類，品種多種多樣，包括：乙酰/甲基轉移酶系列、適配蛋白系列、凋亡通路系列、精氨酸脫亞氨酶系列、細胞周期蛋白系列、細胞應激及分子伴侶蛋白系列、去乙酰化/甲基化酶系列、二氫嘧啶酶系列、雙加氧酶系列、果糖激酶系列、G-蛋白家族產品系列、激酶突變體產品系列、蛋白激酶產品系列、脂質氧化酶系列、微管/肌動蛋白相關蛋白產品系列、磷脂酶C家族產品系列、超氧化物歧化酶產品系列、Tau蛋白及其相關產品系列、轉錄因子產品系列、泛素蛋白產品系列以及無活性激酶產品系列。

五、信號通路相關檢測試劑

該產品系列包括檢測試劑、脂類酶底物、寡氨酸底物、肽底物、蛋白酶底物等產品系列。

六、胞外配體蛋白

該產品系列包括細胞趨化因子、細胞因子及生長因子（生長因子共134種，下表僅列部分）。

品名	貨號	應用
IP-10	I838-40N	Cell Assay
RANTES (CCL5)	R801-40N	Cell Assay
SDF-1	S821-40N	Cell Assay
IFN-gamma	I837-40N
TNF-alpha	T860-40N
TNF-beta	T861-40BG
TNFB	T861-40N
TRAIL	T880-40N

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